1) Grandmother is used to more space for things, where I have half of what she had. I am having to remind her that there is not enough space for things.
2) I work long hours and she knows, but still wants me to do this and that for her when I'm coming home late after 12 hours.
3) She wants to do this and that to my home and yard. I've had to explain to her that it is fine, leave it alone, and that I have my ways of doing things and have for many years. Reminding her that it is my home.
4) She feels the need to be interested in what my neighbors are doing. I have explained to her, not my business, I don't care. Explained that is why I get along with my neighbors.
5) Her need to do things when I don’t have the time. She told me that I should go about my life. I CAN’T when she wants to do things and I don't always have the time being a caregiver for work besides her.
Did she move all her stuff into your house? If so, help her weed through it. Put it in the attic or have her rent a storage unit if she refuses to part with anything. I put mom's stuff in the attic - out of sight, out of mind.
I am an adult now and she STILL doesn't see that!
Since you have a full plate and are limited in what you can do for/with your GM, what are other options for healthy social outlets for her? Volunteer opportunities with a local church or anything else?
Work on finding her another place to live.