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I’m a new caregiver and this is my first post (although I’ve been reading through the forum for several weeks and have to say it has been extremely helpful!).


Some background:
My mother is currently 75 and moved in with me 4 years ago when she was no longer able to work and therefore unable to support herself. (She had been a waitress her whole life, no retirement/savings and unable to live on Social Security alone.)
She has had COPD/emphysema for years along with depression. She also treats with pain management for lower back pain. They give her Lortabs and Gabapentin.
When she first moved in, she had issues with short-term memory loss (asking the same questions over and over) and wouldn’t drive (new city, not familiar with the area). Otherwise, she was self-sufficient. She was able to cook, do laundry, keep track of her medications, go shopping with the neighbor, take the dog out for walks, etc. She also liked to do embroidery and word search puzzles.
She saw a neuropsychologist in 2019 regarding her memory issues. He said she had mild cognitive impairment but could not diagnose dementia.


In mid-June of this year, her older sister passed away and since then things have gone downhill. First, she stopped walking the dog – said she was in too much pain but couldn't say where. Then she started saying odd things that didn’t make sense. Then having trouble walking, losing her balance. Sleeping more. Not being able to articulate her thoughts, find the right words. By mid-August, she was becoming more confused and extremely depressed, crying a lot, wanting to die, scared, saying she felt like she was in a nightmare. She wouldn’t get out of bed, didn’t care about anything. She would repeat the same stories over and over.


Since this started, her PCP has ruled out infections (including UTI), treated anemia, B6 deficiency, done a brain CT (normal) and continues to do bloodwork/urine tests almost weekly. They changed her antidepressant and started titrating her off the Gabapentin. She is no longer crying, etc. which is good. She is still somewhat confused throughout the day, but it gets extremely bad from about 9:00pm until 9:00am. She has no idea where she is or what she is doing. She gets up in the middle of the night to go to the bathroom but goes everywhere except the toilet (dining room chair, bedroom floor, laundry basket). (I now have a monitor to alert me when she gets up.) In addition, she hardly eats/drinks anything now and has lost 20lbs in a month. She only weighed 125lbs to begin with!


It has been 3 months and her PCP still can’t tell me what is wrong with her – whether it is dementia or pseudo-dementia caused by the pain meds and/or depression.
Home Health care sends a PT out 2x week to help her get moving (doesn’t help) and a nurse 1x week to take her vitals. A social worker came out who told me about different placements v. in-home care, but how do I make that decision without knowing what is wrong with her?


She can no longer stay by herself so I haven’t been to my office in over a month. Fortunately, I’m able to work from home right now but not indefinitely so that is another reason I’d like to know what I’m looking at so I can make plans.


I guess what I’m wondering is…is it normal for it to take so long to get answers? Do I need to push harder or go elsewhere for help? I’m at my wits end. I’m watching her waste away and I feel helpless and alone and don't know what to do.


Any insight, suggestions, information is much appreciated.

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Thank you to everyone for your answers, insight and support. We had a tele-visit with the APRN at my mom's PCP's office yesterday (Friday) morning. We see him in between visits with her PCP. (At first I was put off by it but now I find that he speaks more frankly with me than the PCP which I appreciate.) He basically said she is failing to thrive (as suggested by Cover99). The most pressing issue right now is her kidney function due to severe hydration. He ordered a nurse to come to our house to give IV fluids. I was hoping they would come yesterday but I haven't heard from them yet (sigh). At this rate, if things don't improve, we're looking at kidney failure, dialysis, and he gave her about 6 months or less. Hopefully, it won't come to that.
We've been decreasing her Gabapentin slowly but she still takes Lortab for her back pain. Other than those, she was only taking Paxil and Aricept. The APRN added Namenda and a very low dose of Seroquel. The Seroquel is supposed to help with her being confused in the middle of the night about where the toilet is. He said it works right away. Didn't work last night. The alarm I set up in her bedroom went off and I found her sitting at the foot of the bed, diaper pulled down, peeing. I said "what are you doing?" and she replied "I'm peeing" like I had just asked a stupid question. (It's NOT funny but it was kinda funny and sometimes you just have to laugh when you can.)
The APRN also provided a lot of information about AL v. NH and offered to help with forms. So right now we'll see if the re-hydration helps at all and possibly see a nephrologist. I also have an appointment with an elder law attorney in a week to help navigate Medicaid and she sees the neurologist the first of October. So at least I feel like I have somewhat of a plan now.
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In 2 years time, mild cognitive impairment can easily have progressed into full blown dementia, which your mother is exhibiting signs of ie: urinating everywhere but in the toilet and confusion which is much worse in the evenings (Sundowning). See if you can get mom to draw a picture of the face of a clock showing 3 pm or whatever; if she cannot do that and just draws a blob, you will know that her Executive Brain function is compromised. When the EB function is compromised, dementia is at play and that's where the confusion is stemming from. That is, of course, not a 'medical diagnosis' but, combined with the neuro testing and original diagnosis of MCI already given out, it stands to reason your mother has progressed down the dementia path which is normal.

Further intensive testing isn't always necessary, either. My mother has only been given the short MoCa exams over the past 5 years; they last about 15 minutes and are comprised of some memory questions, drawing the clock face, and a few other things. She's scored on a scale from 1-30. Her first score back in 2016 was 18 meaning she had dementia which would progress. It did. In 2019 she tested at 10 and moved into Memory Care Assisted Living.

I don't think you should wait a long time for answers, no, especially b/c your mother is losing weight so rapidly. Dementia patients don't usually lose their appetites or stop eating to THIS degree until the condition has progressed to the late stages. My mother is in the advanced stage of dementia & STILL eats like a truck driver! So I'd get your mom to a different doctor asap, preferably a neurologist, but stress to him or her that intensive long testing is NOT something she wants to be subjected to. I'm sure the doctor can make an assessment of her w/o putting her through hours & hours of rigorous tests!!

I'm sorry you're going through this. Sending you my best wishes for some good answers here to a difficult situation. Also sending you a hug and a prayer.
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Depression can mimic and/or exacerbate dementia, and as you note she was already experiencing some cognitive impairment. It sounds like the PCP is being diligent about ruling out other causes, and is chipping away at the depression, but perhaps your mom's underlying cognitive issues have progressed. What about having the PCP set you up with a follow up with the 2019 neurologist? Or a neuropsychologist? They might be better at managing her meds than the PCP. If you do go back to the neurologist, prior to your visit communicate with them about your mom's new behaviours-either slip them a note, or use e-charting.
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Holyterrier Sep 2021
She originally saw the neuropysch in 2019. It was a 4 hour appointment with memory/cognitive tests and she hated it. She saw a neurologist (actually, the nurse at the neurologist's office) in July of this year. They referred her back to the same neuropsych and we had an appointment but I had to cancel because she hated it and won't go back. She has a follow up appointment with the neurologist in October. I've tried to move the appointment up but they don't have anything sooner.
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Adult Failure to Thrive?
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A very similar thing happened to my mother not long after her only sister died. Her PCP decided she was suffering from depression, when in reality she had pleural effusion and literally couldn't breathe because her chest cavity was full of fluid. I'm convinced the three weeks she was misdiagnosed led to her vascular dementia, and it was downhill from that point on.
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75 years old is not that old these days. Have another doctor evaluate her mental state at this time. The dementia may have progressed. Get connected with a local social worker who can explain what your options are. Talk to the nurse who comes to your mother about your mother's condition and care. With your work responsibilities, your mother might be too much for you to handle in the long term. She may have to move to assisted living or a nursing home. Talk to her doctor about her sleep problems. My mother's doctor prescribed Melatonin, which has to be taken every day. Plan for the dementia to get worse.
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The long term impacts of COPD and depression on brain function haven't been fully studied, but I think it is safe to consider that they each cause more rapid deterioration. The top of the brain - learning new things and making complex decisions - tends to be impacted first - consistent with her move into your home 4 years ago.
Continued brain deterioration over time plus the shock of her sister's death (grief is a physiological and psychological process) may be the culprit in this apparently sudden decline.
The PCP is ruling out the treatable stuff. Changing meds may be a good idea - lortabs are opioids, I believe. Not good for long term use. Low dose of methadone has less side effects and is metabolized more efficiently. Harder for it to build up in the body as the kidneys and liver become less effective in breaking down toxins.
It may be time for residential care of some sort. Take care of yourself, in all of this. Good luck
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No it isn't normal for so many investigations to shed so little light. Whatever is going on, it doesn't seem to be typical of anything. And your mother isn't elderly.

Two questions: what did her sister die of? What does your mother think is wrong?

I wonder if it might be worth revisiting the neuropsych evaluation, do you? This time perhaps with the emphasis on the psych part?

Three questions, sorry - did anyone identify a cause of the anaemia?
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Holyterrier Sep 2021
Her sister died of cancer. It was a long time coming and my mom spoke with her on a video call a few days before she passed. But now she usually doesn't remember that her sister died and when she does remember she thinks it just happened out of nowhere.
Home healthcare is sending out a psych nurse next week, which I'm grateful for, but this was requested LAST week. The delay in getting help is frustrating to say the least.
They gave her iron for the anemia. We originally thought (hoped) that was causing the symptoms but they got her level back up and unfortunately it didn't help.
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Was she very close to her older sister?   Are there any others in her family who are still alive?

This may not sound realistic, but has anyone with a psychiatric background spoken with her and examined her for PTSS?  It isn't military alone who are subject to this syndrome.  And it can present with the symptoms you mention.  The fact that it accelerated after her sister's death suggested to me that that was a trigger.

Animals are used in Veteran PTSS therapy.    Are there any neighbors or acquaintances who can bring their pets over to visit her?  How she responds to them could indicate that pet therapy might be an option.

You could also buy a stuff animal toy for her to gauge her reaction; sometimes people can gain from hugging something soft. 
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Hello. I wonder if a ct was “strong” enough ?

i had an mri which showed lowgrade leukoaraiosis ... white matter disease ... and may not show up on a ct scan ???

i call it “brain sparks” since it doesnt involve alzheimers tangles/placques.

but have enough of those and theres dementia and possible strokes and other undesirable future problems.
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