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Absolutely -- except for mattresses.

Put the stuff on Craigslist or Facebook Marketplace, and they'll be snatched right up, or contact your local senior center. They may have clients who need the items.
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Nextdoor.com is also a great resource where you can post items.
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I have seen things in thrift stores like boxes of adult incontinence supplies. I’ve seen in some goodwill’s walkers, commodes, rollators. Some communities have medical supply closets where things can be purchased at discount and they take donations.
Items you can put in your car might be easier to drop off than advertise.

Some schools have thrift stores for fund raisers. There are thrift stores to raise money for pets. google thrift stores in your community if this is of interest.

In case you need help disposing of prescription drugs:
I recently found out that some drug stores have a powder you can put in prescription bottles and add water and then just put in the garbage with no issue. The powder is free of charge.
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Check with NHs in the area. When I was in charge of the loan shed where I worked we called around to the nursing homes in the area when our donations got more than the shed could handle.
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